Puas yog Nicotinamide Riboside Chloride zoo ib yam li NAD?

Tsis yog, NAD tsis zoo ib yam liNicotinamide riboside chloride (NRCl). Txawm hais tias lawv txoj kev sib raug zoo nruj, lawv yog cov molecules tshwj xeeb nrog cov qauv sib txawv thiab kev ua ub no.

Ob yam tshuaj no feem ntau tsis meej pem los ntawm cov kws kho mob ntxiv thiab cov neeg nyiam noj qab haus huv. Lawv tuaj yeem tham ua ke hauv cov lus hais txog kev laus zoo. Lawv tsis zoo ib yam, txawm li ntawd los. Rau cov neeg siv khoom thiab cov neeg tsim khoom, nws yog qhov tseem ceeb kom nkag siab qhov sib txawv. Powdered NR-Cl ua haujlwm ua ntej. Qhov kawg ua haujlwm coenzyme yog NAD+. Lawv muaj cov haujlwm sib txawv hauv txoj hauv kev ntawm lub zog ntawm tes. Txhawm rau pab koj txiav txim siab zoo, kab lus no tshuaj xyuas qhov sib txawv ntawm kev tshawb fawb ntawm NR nicotinamide riboside thiab NAD+.

Thawj qhov kev sib txawv loj nyob hauv lawv lub cev chemistry. Ob lub tebchaw no zoo sib txawv nyob rau hauv lub tshuab tsom. Lawv kuj muaj ntau yam sib txawv atomic compositions. Peb yuav tsum saib lawv qhov hnyav molecular thiab cov khoom.

 

NRCl: Ib Lub Tsev Kho Mob

Cov tshuajnicotinamide riboside chlorideyog qhov yooj yim. Nws ua haujlwm raws li nicotinamide riboside daim ntawv ntsev ruaj khov. Nicotinamide, ib hom vitamin B3, yog ib feem ntawm cov qauv. Nws muaj ribose qab zib molecule thiab. Txhawm rau kom ruaj ntseg, cov tshuaj chloride ion yog affixed. Vim qhov kev hloov tshiab no, nws tuaj yeem thauj thiab khaws cia. Cov mis rau nws yog C₁₁H₁₅ClN₂O₅. Nws muaj qhov hnyav molecular txog 290.70 g / mol. Nws tuaj yeem txav tau yooj yim vim nws qhov me me. Nws tuaj yeem hla dhau ntawm cov cell membranes.

 

NAD +: Lub complex Dinucleotide

Nicotinamide Adenine Dinucleotide yog hu ua NAD +. Nws yog ib qho kev txiav txim siab loj dua thiab muaj txiaj ntsig ntau dua. Nws yog dinucleotide structurally. Qhov no qhia tau hais tias ob nucleotides txuas rau tsim nws. Muaj adenine puag hauv ib nucleotide. Nicotinamide yog nyob rau hauv lwm yam. Cov nucleotides no koom nrog ob pawg phosphate. Nws muaj ribose pawg thiab. N₇O₁₄P₂ yog nws cov tshuaj formula. Qhov hnyav molecular yog kwv yees li 663.4 g / mol. Qhov no yog ntau tshaj ob zaug loj li NRCl. Cellular nkag yog qhov nyuaj vim nws loj loj yam tsis tau ua ntej tawg.

Chemistry dictates function. Vim tias lawv cov qauv sib txawv, lawv cov haujlwm hauv lub cev kuj txawv. Ib qho yog cov khoom siv raw. Lwm qhov yog cov cuab yeej tiav. Ob leeg yog qhov tseem ceeb rau lub neej. Txawm li cas los xij, lawv ua haujlwm ntawm ntau theem ntawm cov metabolism.

NRCl: Qhov Tseem Ceeb Precursor

Nicotinamide riboside chloride hmoovua qhov tseem ceeb ua tus thawj coj. Xav txog nws yog qhov tseem ceeb "lub tsev thaiv." Lub cev tsis tuaj yeem ua kom txaus NAD + ntawm nws tus kheej. Nws xav tau cov ntaub ntawv raw los ua ke. NRCl muab cov khoom tsim nyog. Thaum noj, nws mus los ntawm cov hlab ntsha. Nws nkag mus rau cov hlwb thiab cov enzymes ua rau nws. Lub cev hloov nws tshwj xeeb los txhawb NAD + qib. Nws tsis ua cov tshuaj tiv thaiv enzymatic nws tus kheej. Nws lub hom phiaj ib leeg yog los ua ib yam dab tsi loj dua.

NAD +: Cellular Cav

NAD + yog lub active coenzyme. Nws yog "tus neeg ua haujlwm" molecule. Nws yog ncaj qha koom nrog ntau dua 500 cov tshuaj tiv thaiv enzymatic. Txhua lub cell cia siab rau nws. Nws plays lub luag haujlwm tseem ceeb hauv kev tsim hluav taws xob. Nws pab hloov zaub mov rau hauv ATP. NAD + kuj tseem ceeb heev rau cov txheej txheem kho DNA. Nws pab txhawb cellular signaling. Sirtuins, ib tsev neeg ntawm cov proteins uas txuas rau lub neej ntev, xav kom NAD + ua haujlwm. Yog tsis muaj cov coenzyme no, cov txheej txheem metabolic tseem ceeb yuav nres.

Kev ruaj ntseg ntawm cov molecule txiav txim siab nws txoj kev lag luam muaj txiaj ntsig. Nws kuj hais tias yuav ua li cas ntxiv yuav ua tau zoo. Tsis yog tag nrho cov molecules ciaj sia txoj kev mus los ntawm lub digestive system.

Vim li cas NRCl dominates lub qhov ncauj lag luam

Nicotinamide riboside chloride hmoovyog chemically ruaj khov. Daim ntawv chloride ntsev tiv thaiv cov molecule. Nws tiv taus degradation los ntawm tshav kub thiab lub teeb zoo dua li lwm cov ntaub ntawv. Qhov no ua rau nws zoo tagnrho rau qhov ncauj ntxiv. Nws yog feem ntau muag li capsules lossis hmoov. Nws tseem nyob tsis tu ncua thaum digestion. Nws muaj bioavailability siab. Qhov no txhais tau tias lub cev tuaj yeem nqus tau zoo. Cov neeg tsim khoom nyiam nws rau cov khoom noj khoom haus thiab cov khoom noj khoom haus. Nws stability ua kom lub neej ntev.

Cov kev txwv ntawm direct NAD + supplementation

NAD + tsis ruaj tsis khov hauv qhov ncauj. Lub molecule yog tsis yooj yim sua. Lub plab acid tuaj yeem degrade nws sai. Txawm hais tias nws ciaj sia digestion, nws loj loj yog ib qho teeb meem. Nws tsis tuaj yeem yooj yim hla ntawm phab ntsa ntawm tes. Feem ntau qhov ncauj NAD + tau tawg mus rau hauv qhov me me ua ntej nqus. Qhov no defeats lub hom phiaj ntawm kev noj tag nrho cov molecule. Cov chaw kho mob qee zaum siv IV infusions. Txawm li cas los xij, txawm tias kev tswj hwm IV muaj kev sib cav txog kev ua tau zoo. Rau cov neeg siv khoom, ncaj qha NAD + tsis tshua muaj kev xaiv zoo tshaj plaws.

Lawv tsis yog tib yam, tab sis lawv txuas. Peb yuav tsum nkag siab txog txoj hauv kev uas txuas rau lawv. Txoj hauv kev no piav qhia vim li cas noj NRCl ua rau NAD + ntau dua. Nws yog ib txoj kab sib dhos lom neeg.

NAD Biosynthesis Pathway

NRCl pib ib ntu ntawm cov xwm txheej. Ua ntej, NRCl yog absorbed rau hauv lub hlwb. Thaum nkag mus rau hauv, cov enzymes nkag mus. Lub enzyme nicotinamide riboside kinase (NRK1 lossis NRK2) pib thawj kauj ruam. Nws phosphorylates lub molecule. Qhov kev txiav txim no tsim nicotinamide mononucleotide (NMN). Qhov no yog theem nrab. Tom ntej no, lwm enzyme hu ua NMN adenylyltransferase (NMNAT) cov kauj ruam hauv. Nws hloov NMN mus rau qhov kawg NAD + molecule. Cov txheej txheem no ua tau zoo. Nws tso cai rau lub cell tswj kev tsim khoom raws li qhov xav tau.

Qhov zoo ntawmnicotinamide riboside chloridenyob ntawm nws qhov chaw. Le-Nutra ua haujlwm nyob rau hauv ib qho chaw loj rau botanical extracts. Peb lub hauv paus tsim nyob hauv Xi'an, Shaanxi, Suav. Lub cheeb tsam no nto moo rau nws cov keeb kwm nplua nuj. Nws tseem yog ib qho chaw niaj hnub rau biotechnology. Qhov chaw thaj chaw muaj qhov tshwj xeeb zoo. Peb muaj kev nkag tau mus rau siab - cov ntaub ntawv zoo. Lub nroog infrastructure txhawb nqa cov thev naus laus zis thev naus laus zis.

Shaanxi muaj kev lig kev cai ntev ntawm cov tshuaj ntsuab. Niaj hnub no, qhov kev lig kev cai no koom nrog kev tshawb fawb niaj hnub. Le-Nutra leverages ib puag ncig no. Peb siv lub xeev- ntawm-- cov chaw kos duab hauv Xi'an. Qhov no ua kom muaj kev tswj xyuas nruj. Peb qhov chaw tso cai rau kev thauj mus los zoo. Peb txuas cov peev txheej ntuj ntawm Tuam Tshoj nrog lub ntiaj teb ua lag luam. Cov neeg yuav khoom tau txais txiaj ntsig los ntawm qhov kev tso tawm tswv yim no. Nws lav qhov khoom ruaj khov thiab cov nqi sib tw.

Hauv kev xaus, thaum lawv sib txheeb, lawv txawv. Nicotinamide riboside chloride yog qhov ruaj khov ua ntej. NAD + yog lub active coenzyme. Rau kev ntxiv, NRCl yog qhov kev xaiv zoo tshaj vim yog bioavailability. Nws txhawb nqa cellular zog thiab noj qab nyob zoo laus. Le-Nutra muaj cov khoom zoo tshaj plaws rau koj lub hom phiaj.

Peb txaus siab rau peb tus kheej rau ntau tshaj 10 xyoo ntawm kev paub hauv cov khoom xyaw ntuj. Peb cov khoom ua tau raws li cov qauv nruj. Nov yog cov lus qhia tshwj xeeb rau peb cov khoom muaj siab - zoo:

• Cov tsos mob: Dawb mus rau lub teeb xim av hmoov
• Specifications: 99% Purity
• Daim ntawv thov tseem ceeb: Cov khoom noj khoom haus, cov khoom noj ua haujlwm, thiab dej haus tsom rau kev txhawb nqa cellular noj qab haus huv thiab lub zog metabolism.
• Daim ntawv pov thawj: COA, TDS, Allergen, Tsis yog GMO, ISO9001

Peb tswj txhua kauj ruam ntawm OEM kev noj haus ntxiv txheej txheem. Qhov no suav nrog kev ceev faj raw khoom mus rau kev xa khoom tiav. Qhov kev sib xyaw ua ke no ua kom muaj kev ruaj ntseg ntau dua. Nws kuj ruaj ntseg tus nqi sib tw rau peb cov neeg siv khoom. Peb muab ntau hom kev siv tshuaj ntau ntau. Cov no suav nrog cov tshuaj ntsiav nyuaj, gummies, softgels, ntsiav tshuaj, kua tee, thiab lwm yam.

Yog tias koj txaus siab rau peb cov khoom thiab xav paub ntau ntxiv lossis tau txais cov lus hais, thov tsis txhob yig tiv tauj peb. Tsuas xa ib qho kev nug rauinfo@lenutra.com. Cia peb ua hauj lwm ua ke thiab tshawb xyuas lub peev xwm ntawm cov khoom xyaw no.

Q1: Puas yog nicotinamide riboside chloride muaj kev nyab xeeb rau kev noj txhua hnub?

A: Yog, nws feem ntau suav hais tias muaj kev nyab xeeb. Cov kev tshawb fawb dav dav txhawb nws qhov profile kev nyab xeeb. Nws ua raws li daim ntawv ntawm Vitamin B3. Cov neeg laus noj qab nyob zoo feem ntau zam nws zoo. Txawm li cas los xij, ua raws li cov lus pom zoo yog qhov tseem ceeb.

Q2: Vim li cas ho tsis yog siv niacin yooj yim (Vitamin B3) xwb?

A: Tsis tu ncua niacin tuaj yeem ua rau dej ntws tawm. Nws yog ib qho tsis xis nyob ntawm daim tawv nqaij. Nicotinamide riboside chloride tsis ua rau qhov dej ntws tawm. Tsis tas li ntawd, nws nkag mus rau NAD + txoj kev khaws cia ncaj qha. Nws feem ntau muaj txiaj ntsig zoo rau kev txhawb nqa NAD + dua li tus qauv niacin.

Cov ntaub ntawv:

1. Bieganowski, P., & Brenner, C. (2004). Kev tshawb pom ntawm nicotinamide riboside ua cov khoom noj khoom haus thiab khaws cia NRK noob tsim kom muaj Preiss-Txoj kev ywj pheej rau NAD+ hauv cov kab mob thiab tib neeg. Cell.
2. Trammell, SA, et al. (2016). Nicotinamide riboside yog tshwj xeeb thiab qhov ncauj bioavailable nyob rau hauv nas thiab tib neeg. Nature Communications.
3. Conze, D., et al. (2019). Kev nyab xeeb thiab cov metabolism hauv lub sijhawm ntev - kev tswj hwm ntawm NIAGEN (nicotinamide riboside chloride) nyob rau hauv ib qho randomized, ob npaug -qhov muag tsis pom, placebo- tswj kev sim tshuaj xyuas ntawm cov neeg laus noj qab nyob zoo. Kev Tshaj Tawm Txog Kev Tshawb Fawb.
4. Mehmel, M., et al. (2020). Nicotinamide Riboside-Lub Xeev ntawm Kev Tshawb Fawb thiab Kev Siv Tshuaj Kho Mob tam sim no. Khoom noj khoom haus.
5. Yoshino, J., Baur, JA, & Imai, SI (2018). NAD + intermediates: biology thiab kho muaj peev xwm ntawm NMN thiab NR. Cell Metabolism.